A chronic myeloid leukemia case with a unique variant Philadelphia translocation: t(9;22;21)(q34;q11;p12)
نویسندگان
چکیده
منابع مشابه
unique variant complex chromosome translocation in myeloid leukemia: report of a case and literature review
background : according to the literature, there are a number of chronic and acute myeloid leukemias with unique, complex chromosome translocations. this study aims to conduct a brief review of the incidence of complex chromosome translocations in myeloid leukemia and reports a case of myeloid leukemia with complex chromosome translocations. methods :we conducted a web-based search for all peer ...
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Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm characterised by the presence of the Philadelphia (Ph) chromosome which is due to the reciprocal translocation, t(9;22)(q34;q11.2). The translocation results in the BCR-ABL1 fusion gene, encoding a constitutively active tyrosine kinase protein which causes the genesis of CML. About 5-10% of newly diagnosed Ph-positive CML patients ...
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ژورنال
عنوان ژورنال: Oncology Letters
سال: 2012
ISSN: 1792-1074,1792-1082
DOI: 10.3892/ol.2012.623